Read the Kuka profinet option manual. It goes into details about the signal mapping of safety inputs and what needs to be satisfied. On the Siemens side you will need to configure the appropriate GSDML in your project, and take special note of the F_DB that is associated with the robot controller. After startup, the profisafe configuration requires user acknowledgement to reintegrate the network, and this is handled through this F_DB. See this thread: How to use the Profisafe communication in TIA portal?
Ultimately it is up to you or a qualified systems engineer to design your safety system in such a way that it meets the needs of your risk assessment.